In the management of ACS, which therapy is recommended alongside reperfusion to reduce clot formation?

• A. Antibiotic therapy
• B. Diuretic therapy
• C. Antiplatelet therapy
• D. Antihistamine therapy

Answer: (C)

In ACS, restoring blood flow is essential, but the risk of re-occlusion remains if platelets keep aggregating at the culprit site. Antiplatelet therapy directly targets this process. Aspirin irreversibly inhibits platelet COX-1, lowering thromboxane A2 and making platelets less likely to clump. Adding a P2Y12 inhibitor blocks the ADP receptor on platelets, further preventing activation and aggregation. Used with reperfusion, this dual approach markedly reduces the chance of new clots forming and improves outcomes. The other options don’t address clot formation—antibiotics treat infection, diuretics manage fluid status, and antihistamines aren’t related to thrombosis in ACS.